From target to decision.
One engine for small molecules and peptides finds candidates, understands what matters, and shows its work.
An end-to-end reasoning pipeline.
Everything is organized in one traceable molecular evidence graph, giving each candidate a connected path from source and structure to mechanism, score, uncertainty, and validation decision.
Your Knowledge
Compounds, peptides, products, assays, experiments, and proprietary research.
Food Vector Database
A growing search space of food-derived and food-inspired molecular representations.
Public Science
Literature, proteins, pathways, structures, ontologies, and biological evidence.
Use candidate-first analysis to map molecules and peptides to plausible targets and mechanisms, or biology-first discovery to identify candidates for a defined target or pathway.
Ligand-First
Give us a small molecule or peptide, and we map the human proteins and pathways it most likely acts on.
Receptor-First
Or give us a target, and we search ZERO STATE’s database of food-derived molecules and peptides for new binders.
Every compound is scored on a full developability profile — ADMET, permeability, stability, and other proven metrics — not a single binding number. The result is one composite rank you can compare fairly from one compound to the next.
Every candidate is explained through the graph, with the exact structures, pathways, and sources behind each claim tracked and traceable. Candidates that need more evidence are flagged, and the most promising experiments to run next are surfaced.
Docking identifies plausible binding modes. Molecular dynamics tests whether those interactions remain stable over time. Free-energy calculations help distinguish durable candidates from attractive false positives.
Binding pose
Identify physically plausible interactions.
Dynamic stability
Test whether binding persists over time.
Confident decision
Separate durable candidates from false positives.
Advance the candidates that remain stable, selective, and physically plausible across methods.
Unlocking the science behind natural therapeutics
Two natural compounds. Anecdotal reports of neurological benefit. No explanation for why they worked. Our mission was to find out — and to do it at a scale no wet lab could match.
Why do these compounds affect the brain?
We docked both compounds against ~5,000 human proteins, then applied Gene Ontology enrichment analysis to reveal which pathways they preferentially engage — far beyond what chance would predict.
What makes this peptide product heal ulcers?
A proprietary product of ~200 peptides, remarkably effective at healing stomach ulcers — but mechanistically unexplained. We applied the same framework to rank the pool and map the proteins behind the healing.
The product doesn’t rely on a single healing mechanism — it engages multiple biological pathways simultaneously. A multi-target mode of action that likely explains its outsized clinical results.
Zero State turns biological puzzles into actionable science — understanding a compound’s mechanism, prioritizing a peptide library, or building the evidence base for your next product, at speed and scale.
Target Identification
Surface novel, disease-relevant targets and rank them by strength of evidence — every candidate arrives with its supporting literature, structures, and pathway context, ready for review.
Mechanism of Action
Explain how a molecule acts across pathways and interacting partners.
Drug Repurposing
Reveal new indications grounded in a clear molecular rationale.
Biomarker Discovery
Connect molecular signatures to disease states and phenotypes.
Off-Target Assessment
Anticipate interactions and safety signals earlier in the pipeline.
Every conclusion is traceable to evidence.
ZERO STATE is designed for scientific scrutiny. Outputs are not opinions — they are conclusions linked to the sources, structures, and reasoning steps that produced them.
Evidence-linked outputs
Every claim cites the sources and data points behind it.
Reproducible reasoning
The same inputs yield the same auditable reasoning path.
Expert-benchmarked
Evaluated against domain review, not intuition alone.
Auditable by design
Full provenance from an insight back to its origin.
A compound candidate modulates the target pathway via JAK/STAT inhibition.